Atalanta Therapeutics
Bioinformatics Analyst/Engineer
Atalanta TherapeuticsUnited States1 day ago
Full-timeResearch, Analyst +1
Building on our founders’ Nobel-prize winning discoveries in RNA interference, Atalanta Therapeutics is developing novel Di-siRNA therapies to treat severe neurological diseases at the root cause. With a robust internal pipeline along with key strategic partnerships in place, Atalanta is poised to make a meaningful difference in people’s lives. We are driven by a culture of integrity, respect, collaboration, and continuous learning. We are located in Boston’s vibrant Seaport district near South Station.

POSITION SUMMARY:

Atalanta Therapeutics is seeking a highly motivated individual to join the Bioinformatics team in support of our growing research efforts. This role offers an exciting opportunity to apply bioinformatics expertise toward first-in-class RNAi drug discovery. The successful candidate will analyze and integrate both public and in-house transcriptomic datasets, leveraging a solid understanding of common bioinformatics file formats. They will independently design, run, and enhance complex Nextflow pipelines, as well as contribute to the development of AI/ML models that predict siRNA efficacy. This position plays a key role in advancing multiple RNAi-based therapeutics targeting neurodegenerative diseases.

RESPONSIBILITIES:

  • Execute drug design algorithm for multiple targets and contribute to expanding the algorithm with key new features.
  • Contribute to the development and operationalization of a new AI/ML model for siRNA efficacy prediction.
  • Analyze transcriptomics data using public and proprietary pipelines and address key questions for drug development such as efficacy and safety.
  • Provide support to manage Atalanta’s bioinformatics cloud environment and develop Nextflow pipelines that answer key biological questions.
  • Collaborate with various research teams and provide genomics and bioinformatics support as needed.

MINIMUM QUALIFICATIONS:

  • A Bachelor’s or Master’s degree in Bioinformatics, Computational Biology, Computer Science or related discipline, with 0-5+ years of industry experience, is required. Level will be commensurate with experience.
  • Understanding of the common transcriptomics and genomics file formats and ability to parse these formats using command-line tools and R scripts.
  • Experience in programming, scripting, querying or statistical analysis languages such as Bash, R, and python is required.
  • Experience with running Nextflow workflows and developing Nextflow pipelines.
  • Experience with Git for committing and tracking code.
  • Understanding of machine learning (ML) techniques and utilizing ML methods with sequence data.
  • Exposure to cloud computing such as AWS, Azure or GCP.
  • Sufficient experience to contribute with minimal training period.
  • Enthusiasm to help design and develop novel therapeutics targeting neurological diseases with a high unmet medical need.

PREFERRED QUALIFICATIONS:

  • Experience in creating dashboards with Plotly Dash, R Shiny, or Tableau.
  • Experience in analyzing human population genomics data and analyze results using R code

Atalanta is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.

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